Segundo pesquisas recentemente publicadas, ao contrário do que se afirmava anteriormente, não são necessárias quatro xícaras de café de cranberrys, mas apenas um copo cheio diário já tem o superpoder de combater vários tipos de câncer.
A pesquisa se baseou na alimentação de camundongos com câncer de cólon adaptada com extrato de cranberry. Com isso, puderam observar que houve uma significativa redução dos tumores em tamanho e número. Com a identificação das moléculas terapêuticas presentes no fruto, ficaria aind a mais fácil a compreensão do seu potencial contra o câncer e, consequentemente, seria melhor a sua utilização.
Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents.
Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased infections to reduced cardiovascular disease and more recently cancer inhibition.
A review of cranberry research targeting cancer revealed positive effects of cranberries or cranberry derived constituents against 17 different cancers utilizing a variety of in vitro techniques, whereas in vivo studies supported the inhibitory action of cranberries toward cancers of the esophagus, stomach, colon, bladder, prostate, glioblastoma and lymphoma. Mechanisms of cranberry-linked cancer inhibition include cellular death induction via apoptosis, necrosis and autophagy; reduction of cellular proliferation; alterations in reactive oxygen species; and modification of cytokine and signal transduction pathways. Given the emerging positive preclinical effects of cranberries, future clinical directions targeting cancer or premalignancy in high risk cohorts should be considered.
Antioxidants (Basel, Switzerland). 2016 Aug 18*** epublish ***
Katherine M Weh, Jennifer Clarke, Laura A Kresty
Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. kweh@mcw.edu., Department of Food Science and Technology, University of Nebraska, 256 Food Innovation Complex, Lincoln, NE 68588-6205, USA. jclarke3@unl.edu., Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. lkresty@mcw.edu.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/27548236
